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Event at Galileo Galilei Institute


School

Frontiers in Nuclear and Hadronic Physics 2021

Online Event
Mar 01, 2021 - Mar 12, 2021



Abstract
The school is primarily addressed to Ph.D. students in Theoretical Nuclear and Hadron Physics. Participation of experimentalists and post-docs is also encouraged. The school will take place from March 1 to March 12, 2021. The school is primarily addressed to Ph.D. students in Theoretical Nuclear and Hadronic Physics. Participation of experimentalists and post-doc fellows is also encouraged. The 2021 edition will be devoted to Nuclear Physics, providing a pedagogical introduction to the basic concepts and tools needed for carrying out research in nuclear structure, nuclear reactions and nuclear astrophysics. The lectures will emphasize the intimate connections among these fields, giving much attention to the interpretation of experimental data. Various theoretical frameworks for the study of nuclear systems will be presented, including both ab initio and more phenomenological approaches.

Topics
G. Colò (Milano Univ.): Density functional theory methods for nuclear physics
A. Drago (Ferrara Univ.): Dense nuclear matter in neutron stars
A. Moro (Sevilla Univ.): Modelling nuclear reactions probing the structure of exotic nuclei
F. Pederiva (Trento Univ.): New computational approaches to nuclear physics
R. Roth (Darmstadt Univ.): Ab initio calculations of nuclear structure


Important Notice:
Due to the coronavirus pandemic, the school will be held online



Organizers
Francesco Becattini (University and INFN, Firenze)
Ignazio Bombaci (University and INFN, Pisa)
Angela Bonaccorso (INFN, Pisa)
Maria Colonna (LNS-INFN, Catania)
Vincenzo Greco (University and LNS-INFN, Catania)
Giovanni Salmè (INFN, Roma)
Elena Santopinto (INFN, Genova)
Enrico Vigezzi (INFN, Milano)


Local organizer
Angela Bonaccorso

Contact
colonna@lns.infn.it
enrico.vigezzi@mi.infn.it

Website
https://www.ggi.infn.it/FNHP






Talks
Date Speaker Title Type Useful Links
Mar 01, 2021 - 08:45-09:00 Opening Talk
Mar 01, 2021 - 09:00-10:45 Gianluca Colò Density functional theory methods for nuclear physics Lecture Video
Mar 01, 2021 - 11:00-12:45 Gong show Discussion
Mar 01, 2021 - 14:30-16:15 Robert Roth Ab initio calculations of nuclear structure Lecture Video
Mar 02, 2021 - 09:00-10:45 Robert Roth Ab initio calculations of nuclear structure Lecture Video
Mar 02, 2021 - 11:00-12:45 Gong show Lecture
Mar 02, 2021 - 14:30-16:15 Gianluca Colò Density functional theory methods for nuclear physics Lecture Video
Mar 03, 2021 - 09:00-10:45 Gianluca Colò Density functional theory methods for nuclear physics Lecture Video
Mar 03, 2021 - 11:00-12:45 Robert Roth Ab initio calculations of nuclear structure Lecture Video
Mar 03, 2021 - 14:30-16:15 Robert Roth EXTRA Ab initio calculations of nuclear structure Lecture Video
Mar 04, 2021 - 09:00-10:45 Francesco Pederiva New computational approaches to nuclear physics Lecture Video
Mar 04, 2021 - 11:00-12:45 Gianluca Colò EXTRA Density functional theory methods for nuclear physics Lecture Video
Mar 04, 2021 - 14:30-16:15 Gianluca Colò Density functional theory methods for nuclear physics Lecture Video
Mar 05, 2021 - 09:00-10:45 Robert Roth Ab initio calculations of nuclear structure Lecture Video
Mar 05, 2021 - 11:00-12:45 Robert Roth & Gianluca Colò Questions Discussion
Mar 05, 2021 - 14:30-16:15 Francesco Pederiva New computational approaches to nuclear physics Lecture Video
Mar 08, 2021 - 09:00-10:45 Alessandro Drago Dense nuclear matter in neutron stars Lecture Video
Mar 08, 2021 - 11:00-12:45 Pietro Faccioli From quarks to Drugs: A Cross-Disciplinary Application of Theoretical Nuclear Physics to Drug Seminar
Abstract

From quarks to Drugs: A Cross-Disciplinary Application of Theoretical Nuclear Physics to Drug

Computer simulations are playing an increasingly important role in several cross-disciplinary fields of Life Science. In particular, microscopic or multi-scale physics-based modelling can in principle be used to investigate the dynamics of biomolecules, thus providing insight into the fundamental mechanisms that drive both their functional and pathological structural changes. Unfortunately, in practice, the applicability of these approaches has been limited, because structural changes in general extremely rare events and because biomolecules are very complex many-body systems. By exploiting functional intergral methods, originally conceived within the framework of subatomic theoretical physics, we have developed cross-disciplinary approaches to overcome this rare-event problem, enabling the direct simulation of fundamental protein structural changes. In particular, these methods have made it possible for the first time to reconstruct the entire folding process of biologically relevant proteins, with an atomic level of resolution. Based on this technological advancement, an entirely new paradigm in rational drug discovery named Pharmacological Protein Inactivation by Folding Intermediate Targeting (PPI-FIT) was recently conceived. This scheme is based on the rationale of blocking the protein folding process, rather than inhibiting the biological function of native proteins. Using the PPI-FIT paradigm we have discovered molecules that can selectively and dose-dependently modulate the cellular expression of the human prion protein, that is involved in severe neurodegenerative diseases. In addition, the PPI-FIT approach has been successfully. applied for drug repurposing, leading to the discovery of molecules capable of repressing the propagation of COVID-19 virus in cellular colonies.

Slides Video
Mar 08, 2021 - 14:30-16:15 Francesco Pederiva New computational approaches to nuclear physics Lecture Video
Mar 09, 2021 - 09:00-10:45 Antonio Moro Modelling nuclear reactions probing the structure of exotic nuclei Lecture Video
Mar 09, 2021 - 11:00-12:45 Francesco Pederiva New computational approaches to nuclear physics Lecture Video
Mar 09, 2021 - 16:30-17:30 Francesco Pederiva Questions Discussion
Mar 10, 2021 - 09:00-10:45 Alessandro Drago Dense nuclear matter in neutron stars Lecture Video
Mar 10, 2021 - 11:00-12:45 Francesco Pederiva EXTRA New computational approaches to nuclear physics Lecture
Mar 10, 2021 - 14:30-16:15 Antonio Moro Modelling nuclear reactions probing the structure of exotic nuclei Lecture Video
Mar 11, 2021 - 09:00-10:45 Antonio Moro Modelling nuclear reactions probing the structure of exotic nuclei Lecture Video
Mar 11, 2021 - 11:00-12:45 Alessandro Drago EXTRA Dense nuclear matter in neutron stars Lecture Video
Mar 11, 2021 - 14:30-16:15 Alessandro Drago Dense nuclear matter in neutron stars Lecture Video
Mar 11, 2021 - 16:30-17:30 Alessandro Drago Questions Discussion
Mar 12, 2021 - 09:00-10:45 Alessandro Drago Dense nuclear matter in neutron stars Lecture Video
Mar 12, 2021 - 11:00-12:45 Antonio Moro EXTRA Modelling nuclear reactions probing the structure of exotic nuclei Lecture Video
Mar 12, 2021 - 14:30-16:15 Antonio Moro Modelling nuclear reactions probing the structure of exotic nuclei Lecture Video
Mar 12, 2021 - 14:30-17:30 Antonio Moro Questions Discussion